1 Title : Detection of Enhancer - Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B - cell
نویسندگان
چکیده
Authors and affiliations: Russell J.H. Ryan1,3,*, Yotam Drier1,3,*, Holly Whitton3, M. Joel Cotton1,3, Jasleen Kaur1,3, Robbyn Issner3, Shawn Gillespie1,3, Charles B. Epstein3, Valentina Nardi1, Aliyah R. Sohani1, Ephraim P. Hochberg2, and Bradley E. Bernstein1,3 Departments of Pathology1, and Medicine2, Massachusetts General Hospital Broad Institute of Harvard University and MIT3 *These authors contributed equally to this work Running Title: Enhancer-Associated Rearrangements in Lymphoma
منابع مشابه
Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma.
UNLABELLED B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called "pinpointing enhancer-associated rearrangements by chromatin immunoprecipitation," or PEAR-ChIP, to simultaneously map enhancer activity and proximal rearrangements in lymphoma cell lines and patient biopsies. This met...
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